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Benzylideneanilines, the condensation products of benzaldehyde and aniline derivatives, have enjoyed significant success as optical metal ion sensors due to their ability to form stable metal complexes which exhibit distinct spectral features compared to the unbound compound. However, their use in aqueous media is limited by the hydrolytic susceptibility of the C=N moiety. Hence, an in-depth investigation into the hydrolytic degradation mechanism of a series of 2-aminophenol derived Nbenzylideneanilines was conducted wherein molecular modelling techniques were applied to elucidate the “step-by-step” transformation mechanism of these compounds from a fundamental perspective.
The burgeoning of small gourmet chocolate boutiques worldwide serves as a key driver for niche and ultra-niche marketing of cocoa (Theobroma cacao L.), branded as (a) geographical indication (b) estate origin or (c) based on unique genetics. Over 90% of the cacao farms globally, are small with an average size between 2 and 5 hectares and can benefit from supplying to the gourmet boutiques.
The majority of scientific discoveries remain confined to dissertations and peer review publications where they remain hidden from their possible industrial applications. Given the challenges offered by current global events like environmental pollution, climate change effects, and diseases, the need for more rapid transmission of scientific discoveries from the realm of postgraduate dissertations and research papers to industrial applications is most critical. Hence, the need for a clear road map, allowing the connection of both pure and applied scientific discoveries to their industrial applications is obvious. Of course, for this to be achieved, a clear understanding of the constituent steps of such a process is germane. Hence, this brief workshop aims to map a possible path for achieving the aforementioned central goal, using previous experiences and examples.
Piano grass (Themeda arguens), reputed to have been introduced to Jamaica as packing material in an imported piano1 . There are about 27 varieties of this highly invasive grass/weed worldwide[1] and in Jamaica the species previously identified as Themeda arguens is of concern as it has progressively taken over lawns, pastures and roadsides [1]. The grass is of particular concern to livestock farmers due to its highly invasive and aggressive nature and the concomitant negative effect on livestock productivity, especially during its annual seeding period (November/December – April) [2], when the palatability of the grass diminishes significantly and the seed awns can cause severe damage to the mouth when consumed, and feet of livestock [2], sometimes requiring veterinary intervention.
The malaria epidemic was responsible for about 241 million infectious cases and 627,000 deaths worldwide in 2020.[1] This infectious disease, transmitted by the female Anopheles mosquito, is caused by parasites of the genus Plasmodium namely P. falciparum, P. vivax, P. malariae, P. knowlesi, P. ovale curtisi and P. ovale wallikeri.[2,3] Also, malaria is found predominantly in the highlands of Africa which accounts for more than 90% of infections worldwide. While there has been some success in the treatment of malaria, its eradication has been negatively impacted by insecticide and drug resistance. With emergence of thiosemicarbazone as antimalarial agents, the combination of pyridine and amide or thioamide moieties into one scaffold makes for an interesting target.[4]
Benzylideneanilines, the condensation products of benzaldehyde and aniline derivatives, have enjoyed significant success as optical metal ion sensors due to their ability to form stable metal complexes which exhibit distinct spectral features compared to the unbound compound. However, their use in aqueous media is limited by the hydrolytic susceptibility of the C=N moiety. Hence, an in-depth investigation into the hydrolytic degradation mechanism of a series of 2-aminophenol derived Nbenzylideneanilines was conducted wherein molecular modelling techniques were applied to elucidate the “step-by-step” transformation mechanism of these compounds from a fundamental perspective.
Lead, a well-known neurotoxin, remains environmentally abundant, arising from many natural and synthetic processes which encourage its environmental accumulation and hence, increased interactions with flora and fauna. Therefore, tremendous research efforts have been invested into developing various methods for its analysis and sequestration, however, affordability, sensitivity and selectivity still remain formidable challenges in this area and hence here is room for further exploration.
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