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The majority of scientific discoveries remain confined to dissertations and peer review publications where they remain hidden from their possible industrial applications. Given the challenges offered by current global events like environmental pollution, climate change effects, and diseases, the need for more rapid transmission of scientific discoveries from the realm of postgraduate dissertations and research papers to industrial applications is most critical. Hence, the need for a clear road map, allowing the connection of both pure and applied scientific discoveries to their industrial applications is obvious. Of course, for this to be achieved, a clear understanding of the constituent steps of such a process is germane. Hence, this brief workshop aims to map a possible path for achieving the aforementioned central goal, using previous experiences and examples.
Science and technology and its application to regional development
The control of invasive species in crops with low tolerance are seen as a public good. This makes it a collective responsibility led by government. This is done directly through public expenditure on control measures or indirectly through incentives to people whose actions may be a contributing factor to the problem. The risks associated with invasive species have been increasing especially with globalization but are changing in nature thus warranting novel strategies for their management.
The malaria epidemic was responsible for about 241 million infectious cases and 627,000 deaths worldwide in 2020.[1] This infectious disease, transmitted by the female Anopheles mosquito, is caused by parasites of the genus Plasmodium namely P. falciparum, P. vivax, P. malariae, P. knowlesi, P. ovale curtisi and P. ovale wallikeri.[2,3] Also, malaria is found predominantly in the highlands of Africa which accounts for more than 90% of infections worldwide. While there has been some success in the treatment of malaria, its eradication has been negatively impacted by insecticide and drug resistance. With emergence of thiosemicarbazone as antimalarial agents, the combination of pyridine and amide or thioamide moieties into one scaffold makes for an interesting target.[4]
Vector-borne diseases have since the 17th century been the leading cause of death by disease more than any other causes combined, even preventing development in the tropics (Gubler 1998). Of all insect vectors, Aedes aegypti proves to be the deadliest as it is the primary vector of the four most notorious vector-borne diseases – chikungunya (chik-V), Zika (Zik-V), dengue fever and yellow fever viruses. Control of the spread of Aedesborne diseases is primarily reliant on the control of the vector responsible for their spread. Traditionally, vector control relied on environmental hygiene and the elimination of breeding sites (Gubler 1998), shifting only in the 1980s to the use of synthetic chemicals in the form of carbamate, organochloride, organophosphate and pyrethroid insecticides (Norris, et al. 2015). However, the evolution of Aedes aegypti resistance to synthetic chemicals have made control of the spread of the vector and its diseases increasingly difficult. This led to the exploration of innovative and alternative methods in the control of Aedes aegypti.
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