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Benzylideneanilines, the condensation products of benzaldehyde and aniline derivatives, have enjoyed significant success as optical metal ion sensors due to their ability to form stable metal complexes which exhibit distinct spectral features compared to the unbound compound. However, their use in aqueous media is limited by the hydrolytic susceptibility of the C=N moiety. Hence, an in-depth investigation into the hydrolytic degradation mechanism of a series of 2-aminophenol derived Nbenzylideneanilines was conducted wherein molecular modelling techniques were applied to elucidate the “step-by-step” transformation mechanism of these compounds from a fundamental perspective.
The control of invasive species in crops with low tolerance are seen as a public good. This makes it a collective responsibility led by government. This is done directly through public expenditure on control measures or indirectly through incentives to people whose actions may be a contributing factor to the problem. The risks associated with invasive species have been increasing especially with globalization but are changing in nature thus warranting novel strategies for their management.
The malaria epidemic was responsible for about 241 million infectious cases and 627,000 deaths worldwide in 2020.[1] This infectious disease, transmitted by the female Anopheles mosquito, is caused by parasites of the genus Plasmodium namely P. falciparum, P. vivax, P. malariae, P. knowlesi, P. ovale curtisi and P. ovale wallikeri.[2,3] Also, malaria is found predominantly in the highlands of Africa which accounts for more than 90% of infections worldwide. While there has been some success in the treatment of malaria, its eradication has been negatively impacted by insecticide and drug resistance. With emergence of thiosemicarbazone as antimalarial agents, the combination of pyridine and amide or thioamide moieties into one scaffold makes for an interesting target.[4]
In recent years there has been a resurgence in interest in psychedelic assisted psychotherapy (PAP) [1]. Initial scientific research into the utilization of these compounds were eventually suspended due to concerns related to increasing recreational use of psychedelics and their association with the rise of the “counterculture movement” in the United States [2]. However, the use of psilocybin and other psychedelics have shown promise in the treatment of mental illnesses. The efficacy of this modality of treatment has been demonstrated through clinical trials and other studies in the management of a number of mental illnesses, including some treatment resistant cases [3].
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