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SYNTHESIS AND ANTIPLASMODIAL EVALUATION OF PYRIDINE CARBOXAMIDES AND THIOCARBOXAMIDES

The malaria epidemic was responsible for about 241 million infectious cases and 627,000 deaths worldwide in 2020.[1] This infectious disease, transmitted by the female Anopheles mosquito, is caused by parasites of the genus Plasmodium namely P. falciparum, P. vivax, P. malariae, P. knowlesi, P. ovale curtisi and P. ovale wallikeri.[2,3] Also, malaria is found predominantly in the highlands of Africa which accounts for more than 90% of infections worldwide. While there has been some success in the treatment of malaria, its eradication has been negatively impacted by insecticide and drug resistance. With emergence of thiosemicarbazone as antimalarial agents, the combination of pyridine and amide or thioamide moieties into one scaffold makes for an interesting target.[4]

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The global essential oils market has been estimated to be US$10.6b in 2021 rising to US$16.0b in 2026 [(Markets, 2021)1] as a result of growth in awareness to preventative healthcare, improvements in the standard of living, along with an increase in the demand for aromatherapy products. With the potential availability of relevant plant materials in Tobago, it is appropriate to develop a strategy for the introduction of Plant Extracts Industry in the island.

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Workshop 2: Become a user and collaborator with BNL and CFN

Brookhaven National Laboratory delivers discovery science and transformative technology to power and secure the nation’s future. Primarily supported by the U.S. Department of Energy’s (DOE) Office of Science, Brookhaven Lab is a multidisciplinary laboratory with seven Nobel Prize-winning discoveries, 37 R&D 100 Awards, and more than 70 years of pioneering research. The laboratory is open to users from all countries and areas of STEM. The workshop will give an introduction to the capabilities of the laboratory, how to access facilities and collaboration tips for working with BNL scientists.

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Psychedelic Assisted Psychotherapy - Preparing your Target Using Psychohistoriography: A Jamaican perspective

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