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In recent years there has been a resurgence in interest in psychedelic assisted psychotherapy (PAP) [1]. Initial scientific research into the utilization of these compounds were eventually suspended due to concerns related to increasing recreational use of psychedelics and their association with the rise of the “counterculture movement” in the United States [2]. However, the use of psilocybin and other psychedelics have shown promise in the treatment of mental illnesses. The efficacy of this modality of treatment has been demonstrated through clinical trials and other studies in the management of a number of mental illnesses, including some treatment resistant cases [3].
The malaria epidemic was responsible for about 241 million infectious cases and 627,000 deaths worldwide in 2020.[1] This infectious disease, transmitted by the female Anopheles mosquito, is caused by parasites of the genus Plasmodium namely P. falciparum, P. vivax, P. malariae, P. knowlesi, P. ovale curtisi and P. ovale wallikeri.[2,3] Also, malaria is found predominantly in the highlands of Africa which accounts for more than 90% of infections worldwide. While there has been some success in the treatment of malaria, its eradication has been negatively impacted by insecticide and drug resistance. With emergence of thiosemicarbazone as antimalarial agents, the combination of pyridine and amide or thioamide moieties into one scaffold makes for an interesting target.[4]
Forensic Crime Scene Investigators (FCSIs) are forensic practitioners who are key components to the investigative process within a legal framework. In fact, the criminal justice system considers the scientific evaluation and forensic evidence collection to be the most significant aspect of any criminal investigation and court cases. Despite this, limited literature exists on the psychological effects experienced by FCSIs from processing gruesome crime scenes on a regular basis.
The worldwide ginger market was valued at US$6.82 billion in 2020, with India, Nigeria and China being the top global producers (Global Ginger Market Report, 2021). Jamaican ginger once held pride of place in the global market, with its widely accepted superior quality, uniqueness of flavor and high oil content. However, since the initial outbreak of the ginger rhizome rot disease in 1995, production has drastically plummeted to insignificant levels and the industry has not yet recovered. In this regard, a number of intervention strategies have been implemented by the Government of Jamaica over the years, including the Eastern Jamaica Agricultural Support Project of 1993 under RADA, the Ginger Agricultural Science, Technology and Innovation Working Group initiative supported by the CTA ACP-EU under the National Commission and Science and Technology in 2005, the Ginger Resuscitation and Expansion Programme of 2011 led by the Export Division of the Ministry of Agriculture, the Ginger Value Chain Study supported by the FAO, the Ginger Varietal Study funded through the Jamaica Business Development Fund in 2018 and the ongoing Ginger Value Chain and Certification Programme supported by the FAO, with propagation and production of disease-free planting materials. These programmes, amounting to investments of millions of dollars, through partnerships with the key private, governmental and international stakeholders, have been met with varying degrees of success.
Benzylideneanilines, the condensation products of benzaldehyde and aniline derivatives, have enjoyed significant success as optical metal ion sensors due to their ability to form stable metal complexes which exhibit distinct spectral features compared to the unbound compound. However, their use in aqueous media is limited by the hydrolytic susceptibility of the C=N moiety. Hence, an in-depth investigation into the hydrolytic degradation mechanism of a series of 2-aminophenol derived Nbenzylideneanilines was conducted wherein molecular modelling techniques were applied to elucidate the “step-by-step” transformation mechanism of these compounds from a fundamental perspective.
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