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Vector-borne diseases have since the 17th century been the leading cause of death by disease more than any other causes combined, even preventing development in the tropics (Gubler 1998). Of all insect vectors, Aedes aegypti proves to be the deadliest as it is the primary vector of the four most notorious vector-borne diseases – chikungunya (chik-V), Zika (Zik-V), dengue fever and yellow fever viruses. Control of the spread of Aedesborne diseases is primarily reliant on the control of the vector responsible for their spread. Traditionally, vector control relied on environmental hygiene and the elimination of breeding sites (Gubler 1998), shifting only in the 1980s to the use of synthetic chemicals in the form of carbamate, organochloride, organophosphate and pyrethroid insecticides (Norris, et al. 2015). However, the evolution of Aedes aegypti resistance to synthetic chemicals have made control of the spread of the vector and its diseases increasingly difficult. This led to the exploration of innovative and alternative methods in the control of Aedes aegypti.
The malaria epidemic was responsible for about 241 million infectious cases and 627,000 deaths worldwide in 2020.[1] This infectious disease, transmitted by the female Anopheles mosquito, is caused by parasites of the genus Plasmodium namely P. falciparum, P. vivax, P. malariae, P. knowlesi, P. ovale curtisi and P. ovale wallikeri.[2,3] Also, malaria is found predominantly in the highlands of Africa which accounts for more than 90% of infections worldwide. While there has been some success in the treatment of malaria, its eradication has been negatively impacted by insecticide and drug resistance. With emergence of thiosemicarbazone as antimalarial agents, the combination of pyridine and amide or thioamide moieties into one scaffold makes for an interesting target.[4]
Economic development theorists ((Schumpter 1942), (Romer, 1994), (Solow, 1956)) have established the theoretical constructs of scientific and technological developments as foundations to innovative solutions in the form of products, processes and services to long-term socio-economic development and prosperity to high-end economies around the world. It is through the pervasiveness of these innovations within markets which then spurs a sustainable social transformation and long term economic growth within nations.
In parallel and distributed computing environments, task scheduling, where the basic idea is minimizing time loss and maximizing performance, is an absolutely critical component. Scheduling in these environments is NP-hard, so it is important that we continue to search and find the most efficient and effective ways of mapping tasks to processors. One such effective approach is known as Ant Colony Optimization (ACO). This popular optimization technique is inspired by the foraging behavior of ants in their colonies to find the shortest paths between their nests and food sources.
Forensic Crime Scene Investigators (FCSIs) are forensic practitioners who are key components to the investigative process within a legal framework. In fact, the criminal justice system considers the scientific evaluation and forensic evidence collection to be the most significant aspect of any criminal investigation and court cases. Despite this, limited literature exists on the psychological effects experienced by FCSIs from processing gruesome crime scenes on a regular basis.
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