LOADING
The malaria epidemic was responsible for about 241 million infectious cases and 627,000 deaths worldwide in 2020.[1] This infectious disease, transmitted by the female Anopheles mosquito, is caused by parasites of the genus Plasmodium namely P. falciparum, P. vivax, P. malariae, P. knowlesi, P. ovale curtisi and P. ovale wallikeri.[2,3] Also, malaria is found predominantly in the highlands of Africa which accounts for more than 90% of infections worldwide. While there has been some success in the treatment of malaria, its eradication has been negatively impacted by insecticide and drug resistance. With emergence of thiosemicarbazone as antimalarial agents, the combination of pyridine and amide or thioamide moieties into one scaffold makes for an interesting target.[4]
Lead, a well-known neurotoxin, remains environmentally abundant, arising from many natural and synthetic processes which encourage its environmental accumulation and hence, increased interactions with flora and fauna. Therefore, tremendous research efforts have been invested into developing various methods for its analysis and sequestration, however, affordability, sensitivity and selectivity still remain formidable challenges in this area and hence here is room for further exploration.
Globally, STEM scientists are the apex of novel innovation and cutting-edge research and development. While, patents are inextricably linked to innovation, research, and development, both undergraduate and graduate STEM students rarely invent, and those that do almost never invent twice. The thesis of this presentation is three-fold: (1) The understanding, value, benefits, and basics of intellectual property (IP) creation and invention are fundamentally missing in STEM curricula; (2) There are few (if any) incentives for STEM researchers to create and file patent applications within the University environment; and (3) Patent filling assistance programs (pro se) provide pro bono outreach and education to applicants. The key tenants of this presentation are reduced to practice as it relates to pro se patent filings of West Indies inspired invention to the United States Patent and Trademark Office (USPTO) in 2021 and 2022. Three examples of West Indies conceived and awarded IP by a lead inventor domiciled in Anguilla, BWI (Patent Nos. 10,934,168, 11,219,255, and 11,298,375). Further, a permanent patent filling, titled: “Innocuous Sterilant using Hemocyanin and Functionalized Fullerenes with Broad-Spectrum Intracellular and Interstitial Microbiocidal and Radical Scavenging Effects for Packaged Matter, Biologics and Organics including Liquids, Gases, Tissue, Organs, Cells, and Limbs with Copper Mediated Oxygenation for Viability and Preservation” is under review and awaiting a first office action offering broad evidence of origination of IP in the West Indies. As case studies for this presentation, two pieces of IP are examined: The permanent patent and a recently filed provisional application that teaches a minimally invasive and unassisted robotic surgical method for atomic scale manipulation of funtionalized nanoparticles to perform high precision “nano surgery”.
Loan management is a complex process that coordinates agreements among multiple stakeholders in such a way that each party benefits from the arrangement [2]. At the core of our work there is the Asset Token (ATK) which is a compliant ERC-20 token and used for all financial transactions in our proposed system. With this token in our private blockchain network [1], stakeholders can interact in a digital market. Our work includes a Non-Fungible Vehicle Token (VTK) and represents the physical vehicle. Users has access to the ownership of this NFT which prevents fraudulent transactions.
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